Euphormins A and B, New Pyranocoumarin Derivatives from Euphorbia formosana Hayata, and Their Anti-Inflammatory Activity.

Yu-Hsuan Lan, I-Hsiao Chen, Hsin-Hung Lu, Ting-Jing Guo, Tsong-Long Hwang, Yann-Lii Leu

Molecules (Basel, Switzerland) 2022 Mar 14

filter terms:

Euphormin-A (1) and euphormin-B (2), two new pyranocoumarin derivatives, and forty known compounds (3-42) were isolated from Euphorbia formosana Hayata (Euphorbiaceae). The chemical structures of all compounds were established based on spectroscopic analyses. Several isolates were evaluated for their anti-inflammatory activity. Compounds 1, 2, 10, 18, 25, and 33 significantly inhibited against superoxide anion generation and elastase release by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Furthermore, compounds 25 and 33 displayed the most potent effects with IC50 values of 0.68 ± 0.18 and 1.39 ± 0.12 µM, respectively, against superoxide anion generation when compared with the positive control (2.01 ± 0.06 µM).

Citation

Yu-Hsuan Lan, I-Hsiao Chen, Hsin-Hung Lu, Ting-Jing Guo, Tsong-Long Hwang, Yann-Lii Leu. Euphormins A and B, New Pyranocoumarin Derivatives from Euphorbia formosana Hayata, and Their Anti-Inflammatory Activity. Molecules (Basel, Switzerland). 2022 Mar 14;27(6)