Expression analysis of IFNAR1 and TYK2 transcripts in COVID-19 patients.

Mohammadarian Akbari, Mehdi Akhavan-Bahabadi, Navid Shafigh, Afshin Taheriazam, Bashdar Mahmud Hussen, Arezou Sayad, Mohadeseh Fathi, Mohammad Taheri, Soudeh Ghafouri-Fard, Mohammad Fathi

Cytokine 2022 May

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As a member of JAK family of non-receptor tyrosine kinases, TYK2 has a crucial role in regulation of immune responses. This protein has a crucial role in constant expression of IFNAR1 on surface of cells and initiation of type I IFN signaling. In the current study, we measured expression of IFNAR1 and TYK2 levels in venous blood samples of COVID-19 patients and matched controls. TYK2 was significantly down-regulated in male patients compared with male controls (RME = 0.34, P value = 0.03). Though, levels of TYK2 were not different between female cases and female controls, or between ICU-admitted and non-ICU-admitted cases. Expression of IFNAR1 was not different either between COVID-19 cases and controls or between patients required ICU admission and non-ICU-admitted cases. However, none of these transcripts can properly diffrentiate COVID-19 cases from controls or separate patients based on disease severity. The current study proposes down-regulation of TYK2 as a molecular mechanism for incapacity of SARS-CoV-2 in induction of a competent IFN response. Copyright © 2022. Published by Elsevier Ltd.

Citation

Mohammadarian Akbari, Mehdi Akhavan-Bahabadi, Navid Shafigh, Afshin Taheriazam, Bashdar Mahmud Hussen, Arezou Sayad, Mohadeseh Fathi, Mohammad Taheri, Soudeh Ghafouri-Fard, Mohammad Fathi. Expression analysis of IFNAR1 and TYK2 transcripts in COVID-19 patients. Cytokine. 2022 May;153:155849