Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19.

George R Abraham, Rhoda E Kuc, Magnus Althage, Peter J Greasley, Philip Ambery, Janet J Maguire, Ian B Wilkinson, Stephen P Hoole, Joseph Cheriyan, Anthony P Davenport

Journal of molecular and cellular cardiology 2022 Jun

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Virus induced endothelial dysregulation is a well-recognised feature of severe Covid-19 infection. Endothelin-1 (ET-1) is the most highly expressed peptide in endothelial cells and a potent vasoconstrictor, thus representing a potential therapeutic target. ET-1 plasma levels were measured in a cohort of 194 Covid-19 patients stratified according to the clinical severity of their illness. Hospitalised patients, including those who died and those developing acute myocardial or kidney injury, had significantly elevated ET-1 plasma levels during the acute phase of infection. The results support the hypothesis that endothelin receptor antagonists may provide clinical benefit for certain Covid-19 patients. Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Citation

George R Abraham, Rhoda E Kuc, Magnus Althage, Peter J Greasley, Philip Ambery, Janet J Maguire, Ian B Wilkinson, Stephen P Hoole, Joseph Cheriyan, Anthony P Davenport. Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19. Journal of molecular and cellular cardiology. 2022 Jun;167:92-96