FTO in cancer: functions, molecular mechanisms, and therapeutic implications.

Yangchan Li, Rui Su, Xiaolan Deng, Yong Chen, Jianjun Chen

Trends in cancer 2022 Jul

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N6-methyladenosine (m6A) is the most abundant internal modification in mRNA that affects RNA processing, stability, and translation. Discovered as the first RNA m6A demethylase, the fat mass and obesity-associated protein (FTO) is frequently dysregulated and plays important roles in various types of cancers. Targeting FTO holds promising therapeutic significance via suppressing tumor growth, potentiating immunotherapy, and attenuating drug resistance. Here, we review recent advances in our understanding of the functions and underlying molecular mechanisms of FTO in tumor development, cancer stem cell (CSC) self-renewal, microenvironment regulation, immunity, and metabolism and discuss the therapeutic potential of targeting FTO for cancer treatment. Copyright © 2022 Elsevier Inc. All rights reserved.

Citation

Yangchan Li, Rui Su, Xiaolan Deng, Yong Chen, Jianjun Chen. FTO in cancer: functions, molecular mechanisms, and therapeutic implications. Trends in cancer. 2022 Jul;8(7):598-614