Targeting mitochondrial proteases for therapy of acute myeloid leukaemia.

Xinrong Xiang, Rui Bao, Yu Wu, Youfu Luo

British journal of pharmacology 2022 Jul

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Targeting cancer metabolism has emerged as an attractive approach to improve therapeutic regimens in acute myeloid leukaemia (AML). Mitochondrial proteases are closely related to cancer metabolism, but their biological functions have not been well characterized in AML. According to different categories, we comprehensively review the role of mitochondrial proteases in AML. This review highlights some 'powerful' mitochondrial protease targets, including their biological function, chemical modulators, and applicative prospect in AML. © 2022 The British Pharmacological Society.

Citation

Xinrong Xiang, Rui Bao, Yu Wu, Youfu Luo. Targeting mitochondrial proteases for therapy of acute myeloid leukaemia. British journal of pharmacology. 2022 Jul;179(13):3268-3282