Advances in the microbial production of the compatible solute ectoine: a review].

Xin Zhang, Zhiwan Shu, Yongzhen Li, Jiangwa Xing, Rong Wang, Guoping Shen, Derui Zhu

Sheng wu gong cheng xue bao = Chinese journal of biotechnology 2022 Mar 25

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Ectoine is an amino acid derivative and an important natural product in halophilic microorganisms. It plays an important role in protecting cells and stabilizing biological macromolecules, and can be widely used in biomedical fields such as drug preparation adjuvants, organ transplantation and preservation, skin wound repair and cosmetics. Due to the medical value and commercial market demand of ectoine, this article summarized the recent advances in the microbial production of ectoine, including the mutation and breeding of hyper-producing strains, construction of genetically and metabolically engineered strains, optimization of fermentation processes, and extraction and purification processes. The application of multi-omics technologies and computational biology to develop an ectoine producing cell factory was prospected, with the aim to provide a reference for ectoine overproduction.

Citation

Xin Zhang, Zhiwan Shu, Yongzhen Li, Jiangwa Xing, Rong Wang, Guoping Shen, Derui Zhu. Advances in the microbial production of the compatible solute ectoine: a review]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2022 Mar 25;38(3):868-881