Highly enantioselective recognition of S-ibuprofen by a host-guest induced chiral nanochannel.

Chirality is an important property, especially for chiral drug enantiomers with huge differences in pharmacology and toxicity. Chiral recognition of drug enantiomers is the first step to understanding the physiological phenomenon and ensuring medical safety. To efficiently identify and isolate these chiral drugs, we prepared a nanochannel. Here, a chiral sensor was fabricated by introducing the host-guest system of pillar[5]arene (WAP5) and phenethylamine into solid-state nanochannels. The chiral guest R-phenethylamine (R-PEA) induced the chirality of the host-guest system and amplified the chiral selectivity for ibuprofen enantiomers in the host-guest-based nanochannels, which was significantly greater than that in the aqueous phase or the R-PEA modified nanochannels. This study provides a strategy to fabricate highly enantioselective nanosensors for chiral drugs.

Citation

Zhuo Liu, Siyun Zhang, Ming Cheng, Lei Yang, Guang Li, Weiwei Xu, Haonan Qu, Feng Liang, Jing Cheng, Haibing Li. Highly enantioselective recognition of S-ibuprofen by a host-guest induced chiral nanochannel. The Analyst. 2022 May 03;147(9):1803-1807

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PMID: 35357379

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