Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

The disrupted surface of porous membranes, commonly used in tissue-chip and cellular coculture systems, is known to weaken cell-substrate interactions. Here, we investigated whether disrupted surfaces of membranes with micron and submicron scale pores affect yes-associated protein (YAP) localization and differentiation of adipose-derived stem cells. We found that these substrates reduce YAP nuclear localization through decreased cell spreading, consistent with reduced cell-substrate interactions, and in turn enhance adipogenesis while decreasing osteogenesis.


Zahra Allahyari, Stephanie M Casillo, Spencer J Perry, Ana P Peredo, Shayan Gholizadeh, Thomas R Gaborski. Disrupted Surfaces of Porous Membranes Reduce Nuclear YAP Localization and Enhance Adipogenesis through Morphological Changes. ACS biomaterials science & engineering. 2022 May 09;8(5):1791-1798

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 35363465

View Full Text