Bromazepam increases the error of the time interval judgments and modulates the EEG alpha asymmetry during time estimation.

This study investigated the bromazepam effects in male subjects during the time estimation performance and EEG alpha asymmetry in electrodes associated with the frontal and motor cortex. This is a double-blind, crossover study with a sample of 32 healthy adults under control (placebo) vs. experimental (bromazepam) during visual time-estimation task in combination with electroencephalographic analysis. The results demonstrated that the bromazepam increased the relative error in the 4 s, 7 s, and 9 s intervals (p = 0.001). In addition, oral bromazepam modulated the EEG alpha asymmetry in cortical areas during the time judgment (p ≤ 0.025). The bromazepam decreases the precision of time estimation judgments and modulates the EEG alpha asymmetry, with greater left hemispheric dominance during time perception. Our findings suggest that bromazepam influences internal clock synchronization via the modulation of GABAergic receptors, strongly relating to attention, conscious perception, and behavioral performance. Copyright © 2022 Elsevier Inc. All rights reserved.

Citation

Paulo Ramiler Silva, Victor Marinho, Francisco Magalhães, Tiago Farias, Daya S Gupta, André Luiz R Barbosa, Bruna Velasques, Pedro Ribeiro, Maurício Cagy, Victor Hugo Bastos, Silmar Teixeira. Bromazepam increases the error of the time interval judgments and modulates the EEG alpha asymmetry during time estimation. Consciousness and cognition. 2022 Apr;100:103317

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PMID: 35364385

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