The relationship between peripheral blood inflammatory markers and diabetic macular edema in patients with severe diabetic retinopathy.

Yan Zhu, Qi Cai, Panpan Li, Yue Zhou, Mudong Xu, Yu Song

Annals of palliative medicine 2022 Mar

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Diabetic macular edema (DME) is a serious complication of diabetic retinopathy (DR). Recent studies have shown that inflammation is closely associated with the development of DME, and peripheral blood inflammatory markers [white blood cell (WBC) count and its subtypes] are relatively simple and easy to detect. Here, we investigated the relationship between peripheral blood inflammatory markers and macular edema in patients with severe DR (including both severe non-proliferative DR and proliferative DR). A total of 42 patients with severe DR were included in this study and divided into two groups: a severe DR with DME group (DME group, n=18) and a severe DR without DME group (non-DME group, n=24). Ophthalmologic findings and hematologic results were retrospectively retrieved from hospitalization records and databases. The neutrophil percentage was significantly higher in the DME group (62.52%±8.21%) than in the non-DME group (57.30%±8.17%) (P<0.05); in contrast, the lymphocyte percentage was significantly lower in the DME group (28.09%±7.45%) than in the non-DME group (33.54%±7.29%) (P<0.05). Logistic regression analysis showed a significant correlation between lymphocyte percentage and DME [odds ratio (OR) =0.654, 95% CI: 0.436-0.851; P=0.011]. Lymphocyte percentage can be used as an inflammatory marker for the development of DME in patients with severe DR.

Citation

Yan Zhu, Qi Cai, Panpan Li, Yue Zhou, Mudong Xu, Yu Song. The relationship between peripheral blood inflammatory markers and diabetic macular edema in patients with severe diabetic retinopathy. Annals of palliative medicine. 2022 Mar;11(3):984-992