Polymorphisms in CTLA-4 predict de novo donor specific antibody formation after kidney transplantation.

Kosuke Ono, Kentaro Ide, Mayu Kashihara, Hiroaki Yamane, Shuji Akimoto, Naoki Tanimine, Hiroyuki Tahara, Masahiro Ohira, Yuka Tanaka, Hideki Ohdan

Human immunology 2022 Jun

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The post-transplant development of donor-specific antibodies (DSAs) initiates the antibody-mediated rejection, which is associated with an increased rate of graft loss. Therefore, risk prediction of de novo DSA (dnDSA) is important for understanding long-term prognostic implications for kidney transplantation outcomes. Cytotoxic T lymphocyte antigen-4 (CTLA-4), a cell surface molecule, suppresses T cell responses. Single-nucleotide polymorphisms (SNPs) in CTLA-4 are known to be associated with acute rejection; however, their association with dnDSA formation is not established. In the present study, we investigated the impact of CTLA-4 SNPs on dnDSA formation after kidney transplantation (KT) by analyzing three CTLA-4 SNPs (rs231775, rs3087243, and rs5742909) in 88 recipients. Patients with the GG genotype of CTLA-4 SNPs rs231775 and rs3087243 had higher rates of dnDSA formation than patients with the AA genotype or heterozygous genotypes. In conclusion, our findings indicate that CTLA-4 SNPs are predisposing factors for dnDSA formation after KT. Copyright © 2022 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

Citation

Kosuke Ono, Kentaro Ide, Mayu Kashihara, Hiroaki Yamane, Shuji Akimoto, Naoki Tanimine, Hiroyuki Tahara, Masahiro Ohira, Yuka Tanaka, Hideki Ohdan. Polymorphisms in CTLA-4 predict de novo donor specific antibody formation after kidney transplantation. Human immunology. 2022 Jun;83(6):494-498