CDC42EP3 promotes glioma progression via regulation of CCND1.

Zhigang Yang, Tao Xu, Tao Xie, Liangliang Yang, Guiping Wang, Yang Gao, Gangming Xi, Xiaobiao Zhang

Cell death & disease 2022 Apr 01

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Gliomas are the most common brain malignancies characterized by high degree of aggressiveness and high mortality. However, the underlying mechanism of glioma progression remains unclear. Here, we probed the role of CDC42EP3 (CDC42 effector protein 3) played in glioma development and its potential downstream mechanism. The expression of CDC42EP3 in tumor and normal brain tissues were examined through immunohistochemistry and we found the likelihood of CDC42EP3 overexpression was positively correlated with pathological grading. Patients with higher expression of CDC42EP3 were more likely to suffer from recurrence as well. Through constructing CDC42EP3-knockdown cell models, we discovered that silencing CDC42EP3 significantly restricted cell proliferation and migration but facilitated cell apoptosis in vitro. Inhibition on tumor growth mediated by CDC42EP3 depletion was further verified in vivo. Regarding downstream target of CDC42EP3, we found that it may positively regulate the expression of CCND1 through c-Myc-mediated transcription. Furthermore, our findings affirmed that effects of CDC42EP3 overexpression on cell proliferation, migration and apoptosis could be confined by depleting CCND1. In a word, this study reported the tumor-promoting role of CDC42EP3 in glioma progression which probably functioned through targeting CCND1. © 2022. The Author(s).

Citation

Zhigang Yang, Tao Xu, Tao Xie, Liangliang Yang, Guiping Wang, Yang Gao, Gangming Xi, Xiaobiao Zhang. CDC42EP3 promotes glioma progression via regulation of CCND1. Cell death & disease. 2022 Apr 01;13(4):290