Bioactive neolignans and lignans from the roots of Paeonia lactiflora.

Huan Xia, Jing-Fang Zhang, Ling-Yan Wang, Gui-Yang Xia, Ya-Nan Wang, Yu-Zhuo Wu, Peng-Cheng Lin, Liang Xiong, Sheng Lin

Chinese journal of natural medicines 2022 Mar

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Two new neolignans and one new lignan (1-3) were obtained from the roots of Paeonia lactiflora. Their structures were unambiguously elucidated based on extensive spectroscopic analysis, single-crystal X-ray crystallography, and the calculated and experimental electronic circular dichroism (ECD) spectra. Compound 1 was a racemic mixture and successfully resolved into the anticipated enantiomers via chiral-phase HPLC. Compound 3 demonstrated moderate inhibitory activity against human carboxylesterase 2A1 (hCES2A1) with an IC50 value of 7.28 ± 0.94 μmol·-1. Copyright © 2022 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

Citation

Huan Xia, Jing-Fang Zhang, Ling-Yan Wang, Gui-Yang Xia, Ya-Nan Wang, Yu-Zhuo Wu, Peng-Cheng Lin, Liang Xiong, Sheng Lin. Bioactive neolignans and lignans from the roots of Paeonia lactiflora. Chinese journal of natural medicines. 2022 Mar;20(3):210-214