Heat shock proteins and the calcineurin-crz1 signaling regulate stress responses in fungi.

Avishek Roy, Ranjan Tamuli

Archives of microbiology 2022 Apr 04

filter terms:

The heat shock proteins (Hsps) act as a molecular chaperone to stabilize client proteins involved in various cell functions in fungi. Hsps are classified into different families such as HSP90, HSP70, HSP60, HSP40, and small HSPs (sHsps). Hsp90, a well-studied member of the Hsp family proteins, plays a role in growth, cell survival, and pathogenicity in fungi. Hsp70 and sHsps are involved in the development, tolerance to stress conditions, and drug resistance in fungi. Hsp60 is a mitochondrial chaperone, and Hsp40 regulates fungal ATPase machinery. In this review, we describe the cell functions, regulation, and the molecular link of the Hsps with the calcineurin-crz1 calcium signaling pathway for their role in cell survival, growth, virulence, and drug resistance in fungi and related organisms. © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Citation

Avishek Roy, Ranjan Tamuli. Heat shock proteins and the calcineurin-crz1 signaling regulate stress responses in fungi. Archives of microbiology. 2022 Apr 04;204(5):240