Bis(2-, 3-, 4-carboxyethylpyridinium) hexafluorosilicates as potential caries prophylactic agents.

Vladimir O Gelmboldt, Irina V Lytvynchuk, Ivan O Shyshkin, Larysa N Khromagina, Marina S Fonari, Victor Ch Kravtsov

Archiv der Pharmazie 2022 Jul

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Interaction of 2-, 3-, 4-carboxyethylpyridines (L1, L2, L3) with fluorosilicic acid results in the corresponding bis(pyridinium) hexafluorosilicates I-III, characterized by elemental analysis, IR, 1 H, 19 F nuclear magnetic resonance (NMR), and mass spectrometry, solubility data, and X-ray crystallography. Crystallographic data: Fdd2, Z = 8, a = 28.610(2) Å, b = 18.8378(14) Å, c = 7.3236(5) Å (I); P-1, Z = 1, a = 6.2712(4) Å, b = 7.1706(5) Å, c = 10.9721(7) Å, α = 102.514(6)°, β = 97.037(5)°, γ = 93.640(6)° (II); P21 /c, Z = 2, a = 10.0345(6) Å, b = 9.8734(5) Å, c = 9.4704(6) Å, β = 94.347(6)° (III). The dominant intermolecular contacts from the Hirshfeld surface analysis are H… F/F… H, H… H, and H… O/O… H with percentages of 33.3%-34.5%, 26.4%-30.0%, and 16.0%-21.8%. The infrared spectra for I-III exhibit stretching vibrations ν(N+ H) at 3300-3050 cm-1 ; stretching and deformation vibrations ν(SiF) and δ(SiF2 ) for [SiF6 ]2- anions are registered near 740 cm-1 and in the range of 480-440 cm-1 . In the 19 F NMR spectra of aqueous solutions of I-III, strong singlet signals of the [SiF6 ]2- anion were registered at δ(F) = -133.35 ppm (I), -131.43 ppm (II), -129.02 ppm (III) with two satellites due to the spin-spin interaction 29 Si-19 F (J(29 Si-19 F) = 107.5 Hz (II), 107.6 Hz (III)). I-III reveal high solubility in water and dimethyl sulfoxide and very poor solubility in methanol and ethanol. All compounds demonstrate noticeable anticaries activity and absence of hepatotoxic effects, and bis(3-carboxyethylpyridinium) hexafluorosilicate II displays the highest caries-preventive efficacy, which significantly exceeds values for the reference preparations, NaF and (NH4 )2 [SiF6 ]. © 2022 Deutsche Pharmazeutische Gesellschaft.

Citation

Vladimir O Gelmboldt, Irina V Lytvynchuk, Ivan O Shyshkin, Larysa N Khromagina, Marina S Fonari, Victor Ch Kravtsov. Bis(2-, 3-, 4-carboxyethylpyridinium) hexafluorosilicates as potential caries prophylactic agents. Archiv der Pharmazie. 2022 Jul;355(7):e2200074