Copper-mediated pentafluoroethylation of organoboronates and terminal alkynes with TMSCF3.

Shitao Pan, Qiqiang Xie, Xiu Wang, Qian Wang, Chuanfa Ni, Jinbo Hu

Chemical communications (Cambridge, England) 2022 Apr 21

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The TMSCF3-derived CuCF2CF3 species has been successfully applied in pentafluoroethylation of organoboronates and terminal alkynes. By using 1,10-phenanthroline as a ligand, a broad range of (hetero)arylboronates and alkenylboronates were smoothly pentafluoroethylated under aerobic conditions. Furthermore, terminal alkynes can undergo aerobic cross-coupling with the TMSCF3-derived CuCF2CF3 species in the absence of additional ligands.

Citation

Shitao Pan, Qiqiang Xie, Xiu Wang, Qian Wang, Chuanfa Ni, Jinbo Hu. Copper-mediated pentafluoroethylation of organoboronates and terminal alkynes with TMSCF3. Chemical communications (Cambridge, England). 2022 Apr 21;58(33):5156-5159