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    Keratoconus is an ectatic corneal disorder and characterized by central and/or inferior temporal corneal thinning in a cone shape. Studies have shown that its pathogenesis is related to changes in tissue proteins, enzymes, immune functions and specific genes, but the exact pathogenesis has not been clearly clarified yet. Hormones such as sex hormones have been found to be associated with keratoconus. This review aims to summarize and analyze the research progress of the effect of hormones on keratoconus and its mechanism, so as to explore the role of hormones in the early diagnosis of keratoconus and find new targets in the treatment of keratoconus, providing reference for clinical work.


    X R Zhao, Y F Yuan, Y Zhang, Y G Chen. Effect of hormones on keratoconus and its mechanism]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology. 2022 Apr 11;58(4):309-314

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    PMID: 35391519

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