Cu-Catalyzed Dual C-O Bonds Cleavage of Cyclic Ethers with Carboxylic Acids, NaI, and TMSCF3 to Give Iodoalkyl Ester.

Dong Lu, Wenjian Guan, Xiaogang Yang, Yuzhi Wang, Nobuaki Kambe, Renhua Qiu

Organic letters 2022 Apr 22

filter terms:

Herein, by dual C-O bond cleavage of cyclic ethers with Cu catalysis, we eventually led to the development of a selective three-component coupling of commercially available chemicals, carboxylic acids, ethers, and halogens to synthesize more than 70 iodoalkyl esters in the presence of TMSCF3. This allows for the concise synthesis of highly functionalized iodoalkyl esters directly. And the synthetic insect pheromones were also disclosed.

Citation

Dong Lu, Wenjian Guan, Xiaogang Yang, Yuzhi Wang, Nobuaki Kambe, Renhua Qiu. Cu-Catalyzed Dual C-O Bonds Cleavage of Cyclic Ethers with Carboxylic Acids, NaI, and TMSCF3 to Give Iodoalkyl Ester. Organic letters. 2022 Apr 22;24(15):2826-2831