Methionine cycle in nonalcoholic fatty liver disease and its potential applications.

Haoyu Wang, Yanwei Wu, Wei Tang

Biochemical pharmacology 2022 Jun

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As a chronic metabolic disease affecting epidemic proportions worldwide, the pathogenesis of Nonalcoholic Fatty Liver Disease (NAFLD) is not clear yet. There is also a lack of precise biomarkers and specific medicine for the diagnosis and treatment of NAFLD. Methionine metabolic cycle, which is critical for the maintaining of cellular methylation and redox state, is involved in the pathophysiology of NAFLD. However, the molecular basis and mechanism of methionine metabolism in NAFLD are not completely understood. Here, we mainly focus on specific enzymes that participates in methionine cycle, to reveal their interconnections with NAFLD, in order to recognize the pathogenesis of NAFLD from a new angle and at the same time, explore the clinical characteristics and therapeutic strategies. Copyright © 2022 Elsevier Inc. All rights reserved.

Citation

Haoyu Wang, Yanwei Wu, Wei Tang. Methionine cycle in nonalcoholic fatty liver disease and its potential applications. Biochemical pharmacology. 2022 Jun;200:115033