Eight undescribed steroidal saponins including an unprecedented 16, 26-epoxy-furostanol saponin from Solanum xanthocarpum and their cytotoxic activities.

Zhen-Peng Xu, Yan Liu, Si-Yi Wang, Zi-Wei Li, Xiao-Mao Li, Dong-Xu Lu, Juan Pan, Hai-Xue Kuang, Bing-You Yang

Phytochemistry 2022 Jul

filter terms:

Eight undescribed steroidal saponins named solasaponins A-H were isolated from the fruits of Solanum xanthocarpum, including an unusual 16,26-epoxy-furostanol saponin, two furostanol saponins, three isospirostanol saponins, two pseudo-spirostanol saponins. The structures of all compounds were elucidated by extensive spectroscopic data analyses (1D, 2D NMR, and HRESIMS) combined with physico-chemical analysis methods (acid hydrolysis, optical rotation, and IR). The cytotoxicities of all compounds in vitro against two human cancer cell lines (A-549 and HepG2) were evaluated by CCK-8 assay. Copyright © 2022 Elsevier Ltd. All rights reserved.

Citation

Zhen-Peng Xu, Yan Liu, Si-Yi Wang, Zi-Wei Li, Xiao-Mao Li, Dong-Xu Lu, Juan Pan, Hai-Xue Kuang, Bing-You Yang. Eight undescribed steroidal saponins including an unprecedented 16, 26-epoxy-furostanol saponin from Solanum xanthocarpum and their cytotoxic activities. Phytochemistry. 2022 Jul;199:113171