Progesterone and Inflammatory Response in the Oviduct during Physiological and Pathological Conditions.

Emily A McGlade, Akio Miyamoto, Wipawee Winuthayanon

Cells 2022 Mar 23

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Progesterone has been shown to be a potent suppressor of several inflammatory pathways. During pregnancy, progesterone levels increase, allowing for normal pregnancy establishment and maintenance. The dysregulation of progesterone, as well as inflammation, leads to poor pregnancy outcomes. However, it is unclear how progesterone imbalance could impact inflammatory responses in the oviduct and subsequently result in early pregnancy loss. Therefore, in this review, we describe the role of progesterone signaling in regulating the inflammatory response, with a focus on the oviduct and pathological conditions in the Fallopian tubes.

Citation

Emily A McGlade, Akio Miyamoto, Wipawee Winuthayanon. Progesterone and Inflammatory Response in the Oviduct during Physiological and Pathological Conditions. Cells. 2022 Mar 23;11(7)