Metastasis and MAPK Pathways.

Mateusz Kciuk, Adrianna Gielecińska, Adrianna Budzinska, Mariusz Mojzych, Renata Kontek

International journal of molecular sciences 2022 Mar 31

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Cancer is a leading cause of death worldwide. In many cases, the treatment of the disease is limited due to the metastasis of cells to distant locations of the body through the blood and lymphatic drainage. Most of the anticancer therapeutic options focus mainly on the inhibition of tumor cell growth or the induction of cell death, and do not consider the molecular basis of metastasis. The aim of this work is to provide a comprehensive review focusing on cancer metastasis and the mitogen-activated protein kinase (MAPK) pathway (ERK/JNK/P38 signaling) as a crucial modulator of this process.

Citation

Mateusz Kciuk, Adrianna Gielecińska, Adrianna Budzinska, Mariusz Mojzych, Renata Kontek. Metastasis and MAPK Pathways. International journal of molecular sciences. 2022 Mar 31;23(7)