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    To explore the potential application of B-OT in the aspiration tract. We conceived and optimized an in vitro model simulating the mouth-washing process to assess tolerance to B-OT on primary human gingival fibroblasts. Cells derived from 4 unrelated donors were flushed with medium containing drugs of various concentration for one minute twice daily for 3 days. No effect was seen on the cells up to 1000 µM B-OT. In addition, we treated the cells with B-OT permanently in medium, corresponding to a systemic treatment. No effect was seen by 10 µM B-OT and only a slight reduction (approximately 10%) was seen by 100 µM B-OT. Our results suggest good tolerance of oral cells for B-OT, favoring the further development of this antiviral reagent as a mouth-washing solution and nasal spray.


    Ming Yan, Ralf Smeets, Martin Gosau, Tobias Vollkommer, Sandra Fuest, Eva Stetzer, Lan Kluwe, Johannes F Coy, Simon Burg. Tolerance of Human Fibroblasts to Benfo-Oxythiamine In Vitro. International journal of environmental research and public health. 2022 Mar 30;19(7)

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    PMID: 35409800

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