miR-146a Protects against Staphylococcus aureus-Induced Osteomyelitis by Regulating Inflammation and Osteogenesis.

Chaolai Jiang, Yiwei Lin, Haojie Shan, Wenyang Xia, Chenhao Pan, Nan Wang, Lihui Zhou, Youshui Gao, Zubin Zhou, Xiaowei Yu

ACS infectious diseases 2022 May 13

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Osteomyelitis is a Staphylococcus aureus-caused bone infection. In this study, the effects of miR-146a on osteomyelitis were evaluated. Using the osteoblast cell model and S. aureus-induced osteomyelitis mice model, we monitored the miR-146 expression and explored the effects of miR-146a on cell proliferation of osteoblasts, bone remodeling, osteoclastogenesis, inflammatory cytokine production, and bacterial burden. Upregulated miR-146a was found in mice with S. aureus-induced osteomyelitis. miR-146a attenuated S. aureus-induced cell loss of osteoblasts, rescued the expression of osteogenic markers, altered the bone remodeling, and inhibited inflammatory cytokine production and osteoclastogenesis. miR-146a knockout mice had higher S. aureus burden. In conclusion, miR-146a protects against S. aureus-induced osteomyelitis by regulating inflammation and osteogenesis.

Citation

Chaolai Jiang, Yiwei Lin, Haojie Shan, Wenyang Xia, Chenhao Pan, Nan Wang, Lihui Zhou, Youshui Gao, Zubin Zhou, Xiaowei Yu. miR-146a Protects against Staphylococcus aureus-Induced Osteomyelitis by Regulating Inflammation and Osteogenesis. ACS infectious diseases. 2022 May 13;8(5):918-927