Breaching B cell tolerance in the tumor microenvironment.

Allyson C Banville, Brad H Nelson

Cancer cell 2022 Apr 11

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The immune system employs complex tolerance mechanisms in order to avoid harmful autoimmunity, yet autoantibodies are frequently observed in cancer. In a paper in Cell, Mazor et al. report that autoantibodies produced by tumor-infiltrating B cells in human ovarian cancer frequently recognize the self-protein matrix metalloproteinase 14 (MMP14) through two distinct mechanisms of tolerance disruption. Copyright © 2022 Elsevier Inc. All rights reserved.