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The immune system employs complex tolerance mechanisms in order to avoid harmful autoimmunity, yet autoantibodies are frequently observed in cancer. In a paper in Cell, Mazor et al. report that autoantibodies produced by tumor-infiltrating B cells in human ovarian cancer frequently recognize the self-protein matrix metalloproteinase 14 (MMP14) through two distinct mechanisms of tolerance disruption. Copyright © 2022 Elsevier Inc. All rights reserved.


Allyson C Banville, Brad H Nelson. Breaching B cell tolerance in the tumor microenvironment. Cancer cell. 2022 Apr 11;40(4):356-358

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PMID: 35413269

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