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We use terahertz (THz) time-domain spectroscopy (TDS) to assess the crystalline state of indomethacin (IM) when loaded in smartFilms®. We found that smartFilms favour the amorphous IM (A-IM) for low loading concentrations. For higher concentrations, IM recrystallizes in its [Formula: see text]- crystalline form and the amount of A-IM in the smartFilms reduces. Both, [Formula: see text]- and A-IM are preferred over the more common [Formula: see text]- crystalline form, as they exhibit better water solubility, which can increase the oral bioavailability of the drug. © 2022. The Author(s).


Jan Ornik, Lara Heidrich, Robert Schesny, Enrique Castro-Camus, Cornelia M Keck, Martin Koch. Non-destructive crystallinity assessment of indomethacin in tablets made from smartFilms® using terahertz time-domain spectroscopy. Scientific reports. 2022 Apr 12;12(1):6099

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PMID: 35414681

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