Determination of zaleplon and clobazam by high performance liquid chromatography - high resolution tandem mass spectrometry using Orbitrap technology].

R A Kalyokin, N E Moskaleva, A A Volkova, A M Orlova, P A Markin, S R Nevmyatova, S A Appolonova

Sudebno-meditsinskaia ekspertiza 2022

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Was to develop a method for the qualitative and quantitative determination of benzodiazepine receptor agonists (zaleplon and clobazam), taking into account different chemical structures, by high-performance liquid chromatography-high-resolution tandem mass spectrometry using Orbitrap technology for the purposes and tasks of forensic medical examination. A method has been developed for the identification and quantitative determination of zaleplon and clobazam by high-performance liquid chromatography-high-resolution tandem mass spectrometry using Orbitrap technology. The proposed identification method can be used in the future to form a database of domestic mass spectra for potent and narcotic substances.

Citation

R A Kalyokin, N E Moskaleva, A A Volkova, A M Orlova, P A Markin, S R Nevmyatova, S A Appolonova. Determination of zaleplon and clobazam by high performance liquid chromatography - high resolution tandem mass spectrometry using Orbitrap technology]. Sudebno-meditsinskaia ekspertiza. 2022;65(2):24-28