The phosphate ester group in secondary metabolites.

Covering: 2000 to mid-2021The phosphate ester is a versatile, widespread functional group involved in a plethora of biological activities. Its presence in secondary metabolites, however, is relatively rare compared to other functionalities and thus is part of a rather unexplored chemical space. Herein, the chemistry of secondary metabolites containing the phosphate ester group is discussed. The text emphasizes their structural diversity, biological and pharmacological profiles, and synthetic approaches employed in the phosphorylation step during total synthesis campaigns, covering the literature from 2000 to mid-2021.

Citation

Franco Della-Felice, Aloisio de Andrade Bartolomeu, Ronaldo Aloise Pilli. The phosphate ester group in secondary metabolites. Natural product reports. 2022 May 26;39(5):1066-1107

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PMID: 35420073

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