Simple silver(I)-salt catalyzed selective hydroboration of isocyanates, pyridines, and quinolines.

AgSbF6 has been established as an effective catalyst for the hydroboration of structurally and electronically diverse isocyanates under ligand- and solvent-free conditions which selectively yielded either N-boryl formamides or N-boryl methylamines under different conditions. Further, various N-heterocycles can be selectively hydroborated using this simple catalytic system; pyridine derivatives undergo preferential 1,4 hydroboration whereas the formation of tetrahydroquinoline (after hydrolysis) via complete heterocycle hydrogenation was observed for quinolines.

Citation

Vipin K Pandey, Sangita Sahoo, Arnab Rit. Simple silver(I)-salt catalyzed selective hydroboration of isocyanates, pyridines, and quinolines. Chemical communications (Cambridge, England). 2022 May 03;58(36):5514-5517

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PMID: 35420096

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