Double life: How GRK2 and β-arrestin signaling participate in diseases.

G-protein coupled receptor (GPCR) kinases (GRKs) and β-arrestins play key roles in GPCR and non-GPCR cellular responses. In fact, GRKs and arrestins are involved in a plethora of pathways vital for physiological maintenance of inter- and intracellular communication. Here we review decades of research literature spanning from the discovery, identification of key structural elements, and findings supporting the diverse roles of these proteins in GPCR-mediated pathways. We then describe how GRK2 and β-arrestins partake in non-GPCR signaling and briefly summarize their involvement in various pathologies. We conclude by presenting gaps in knowledge and our prospective on the promising pharmacological potential in targeting these proteins and/or downstream signaling. Future research is warranted and paramount for untangling these novel and promising roles for GRK2 and arrestins in metabolism and disease progression. Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Citation

Ruxu Zhai, Jonathan Snyder, Sarah Montgomery, Priscila Y Sato. Double life: How GRK2 and β-arrestin signaling participate in diseases. Cellular signalling. 2022 Apr 14;94:110333

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PMID: 35430346

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