An Overview of Treatment Guidelines and Methods of Synthesis of Drugs Used in Leprosy Chemotherapy.

Luiz C S Pinheiro, Julio C Borges, Vinicius R Campos, Leonardo C Dantas

Mini reviews in medicinal chemistry 2023

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Leprosy is a Neglected Tropical Disease (NTDs) caused by Mycobacterium leprae (M. leprae). The treatment is considered effective, however, the high dose Multidrug Therapy (MDT) for a long period and its adverse effects result in the abandonment of the treatment by patients. Indeed, antimicrobial resistance is still an obstacle that must be overcome in the treatment of leprosy. In the present article, we reviewed the WHO guidelines for the chemotherapy of leprosy and the methods of synthesis of these drugs. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Citation

Luiz C S Pinheiro, Julio C Borges, Vinicius R Campos, Leonardo C Dantas. An Overview of Treatment Guidelines and Methods of Synthesis of Drugs Used in Leprosy Chemotherapy. Mini reviews in medicinal chemistry. 2023;23(4):497-512