Palladium-Catalyzed Asymmetric Dearomative Carbonylation of Indoles.

Herein, we disclose a strategy for the asymmetric dearomatization of N-arylacyl indoles via a palladium-catalyzed tandem Heck/carbonylation, leading to an array of indoline-3-carboxylates bearing vicinal C2-aza-quaternary and C3 tertiary stereocenters in high yields and excellent enantio- and diastereoselectivities. This study is an important advance in the field of asymmetric carbonylation and enantioselective dearomatization reactions.

Citation

Qiuyu Li, Yunchu Zhang, Yuye Zeng, Yujing Fan, Aijun Lin, Hequan Yao. Palladium-Catalyzed Asymmetric Dearomative Carbonylation of Indoles. Organic letters. 2022 Apr 29;24(16):3033-3037

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PMID: 35436128

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