Correlation Engine 2.0
Clear Search sequence regions


  • AQP4 (8)
  • cell density (1)
  • cell membrane (2)
  • signal (2)
  • Sizes of these terms reflect their relevance to your search.

    The purpose of this study was to compare parameter estimates for the 2-compartment and diffusion kurtosis imaging models obtained from diffusion-weighted imaging (DWI) of aquaporin-4 (AQP4) expression-controlled cells, and to look for biomarkers that indicate differences in the cell membrane water permeability. DWI was performed on AQP4-expressing and non-expressing cells and the signal was analyzed with the 2-compartment and diffusion kurtosis imaging models. For the 2-compartment model, the diffusion coefficients (Df, Ds) and volume fractions (Ff, Fs, Ff = 1-Fs) of the fast and slow compartments were estimated. For the diffusion kurtosis imaging model, estimates of the diffusion kurtosis (K) and corrected diffusion coefficient (D) were obtained. For the 2-compartment model, Ds and Fs showed clear differences between AQP4-expressing and non-expressing cells. Fs was also sensitive to cell density. There was no clear relationship with the cell type for the diffusion kurtosis imaging model parameters. Changes to cell membrane water permeability due to AQP4 expression affected DWI of cell suspensions. For the 2-compartment and diffusion kurtosis imaging models, Ds was the parameter most sensitive to differences in AQP4 expression.

    Citation

    Akiko Imaizumi, Takayuki Obata, Jeff Kershaw, Yasuhiko Tachibana, Yoichiro Abe, Sayaka Shibata, Nobuhiro Nitta, Ichio Aoki, Masato Yasui, Tatsuya Higashi. Quantitative measurement of diffusion-weighted imaging signal using expression-controlled aquaporin-4 cells: Comparative study of 2-compartment and diffusion kurtosis imaging models. PloS one. 2022;17(4):e0266465

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 35439261

    View Full Text