Actomyosin fibers DApPLE epithelial apical junctions.

Epithelial cell morphology is essential for cellular homeostasis, but the mechanisms by which cell shape is established remain unclear. In this study, Marivin et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202111002) identify DAPLE as a linker between polarity complexes and the actomyosin network at apical junctions. By recruiting CD2P and activating Gαβγ-mediated RhoA signaling, DAPLE ensures proper cell shape and function. © 2022 Manzano and Martin-Belmonte.

Citation

Alejandra R Manzano, Fernando Martín-Belmonte. Actomyosin fibers DApPLE epithelial apical junctions. The Journal of cell biology. 2022 May 02;221(5)

Mesh Tags

Substances

PMID: 35442398

search → result