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This case was a 73-year-old woman who previously underwent a partial colectomy for ascending colon cancer at the age of 70. She had a history of cancer of the uterus, descending colon, bladder, and left ureter. She had a family history of colorectal cancer and met the Amsterdam Ⅱ criteria for Lynch syndrome. She was diagnosed as Lynch syndrome with a MSH2 germline mutation by genetic analysis. One year later, a partial colectomy was performed for sigmoid colon cancer. Six months later, colonofiberscopy revealed early-stage cancer in the rectum, and EMR was performed. Despite adequate surveillance, she had frequent recurrences of advanced colorectal cancer within a short period of time. We report here risk factors of colorectal cancer in Lynch syndrome and indications for prophylactic total colectomy.


Akio Kawasumi, Norimitsu Shimada, Yosuke Shimizu, Haruki Sada, Kanako Suzuki, Shinji Yamaguchi, Syo Tazuma, Syuji Akimoto, Naoto Hadano, Hirofumi Tazawa, Takahisa Suzuki, Takashi Onoe, Takeshi Sudo, Hirotaka Tashiro. A Case of Lynch Syndrome with Repeated Asynchronous Colorectal Cancer in a Short Period]. Gan to kagaku ryoho. Cancer & chemotherapy. 2022 Apr;49(4):467-469

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PMID: 35444138

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