Phenylpropanoids from Solanum capsicoides and their anti-inflammatory activity.

Two new phenylpropanoids, 4-O-(1''-O-cis-caffeoyl)-β-glucopyran osyl-1-allyl-3-methoxy-benzene (1), 4'-O-(1''-O-cis-caffeoyl)-β-glucopyranosyl-hydroxymegastigm-4-en-3-one (2), together with nine known compounds were obtained from the leaves of Solanum capsicoides. Their structures were elucidated based on spectroscopic methods, and comparing spectral data with those in literature. Meanwhile, their anti-inflammatory activities were evaluated on (LPS)-induced RAW 246.7 cells, and 1, 9, and 10 showed better inhibitory effects with IC50 values of 17.19 ± 1.12, 18.15 ± 0.47, and 19.8 ± 0.95 μM, respectively.

Citation

Han Wang, Yan Liu, Yi-Kai Jang, Si-Yi Wang, Xiao-Mao Li, Juan Pan, Wei Guan, Adnan Mohammed Algradi, Hai-Xue Kuang, Bing-You Yang. Phenylpropanoids from Solanum capsicoides and their anti-inflammatory activity. Journal of Asian natural products research. 2023 Feb;25(2):118-124

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PMID: 35446733

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