Insulin Receptors and Insulin Action in the Heart: The Effects of Left Ventricular Assist Devices.

Konstantina Pantazi, Eleni Karlafti, Alexandra Bekiaridou, Matthaios Didagelos, Antonios Ziakas, Triantafyllos Didangelos

Biomolecules 2022 Apr 14

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This year, 2022, marks the 100th anniversary of the isolation of human insulin and its administration to patients suffering from diabetes mellitus (DM). Insulin exerts many effects on the human body, including the cardiac tissue. The pathways implicated include the PKB/Akt signaling pathway, the Janus kinase, and the mitogen-activated protein kinase pathway and lead to normal cardiac growth, vascular smooth muscle regulation, and cardiac contractility. This review aims to summarize the existing knowledge and provide new insights on insulin pathways of cardiac tissue, along with the role of left ventricular assist devices on insulin regulation and cardiac function.

Citation

Konstantina Pantazi, Eleni Karlafti, Alexandra Bekiaridou, Matthaios Didagelos, Antonios Ziakas, Triantafyllos Didangelos. Insulin Receptors and Insulin Action in the Heart: The Effects of Left Ventricular Assist Devices. Biomolecules. 2022 Apr 14;12(4)