Correlation Engine 2.0
Clear Search sequence regions

  • genomes (1)
  • human (1)
  • livestock (1)
  • mammals (1)
  • melanocortin (1)
  • retrotransposon (7)
  • Sizes of these terms reflect their relevance to your search.

    The diversity of livestock coat color results from human positive selection and represents an indispensable part of breed identity. As an important biodiversity resource, pigs have many special characteristics, including the most visualized feature, coat color, and excellent adaptation, and the coat color represents an important phenotypic characteristic of the pig breed. Exploring the genetic mechanisms of phenotypic characteristics and the melanocortin system is of considerable interest in domestic animals because their energy metabolism and pigmentation have been under strong selection. In this study, 20 genes related to coat color in mammals were selected, and the structural variations (SVs) in these genic regions were identified by sequence alignment across 17 assembled pig genomes, from representing different types of pigs (miniature, lean, and fat type). A total of 167 large structural variations (>50 bp) of coat-color genes, which overlap with retrotransposon insertions (>50 bp), were obtained and designated as putative RIPs. Finally, 42 RIPs were confirmed by PCR detection. Additionally, eleven RIP sites were further evaluated for their genotypic distributions by PCR in more individuals of eleven domesticated breeds representing different coat color groups. Differential distributions of these RIPs were observed across populations, and some RIPs may be associated with breed differences.


    Zhanyu Du, Enrico D'Alessandro, Yao Zheng, Mengli Wang, Cai Chen, Xiaoyan Wang, Chengyi Song. Retrotransposon Insertion Polymorphisms (RIPs) in Pig Coat Color Candidate Genes. Animals : an open access journal from MDPI. 2022 Apr 08;12(8)

    PMID: 35454216

    View Full Text