Carica papaya Leaf Juice for Dengue: A Scoping Review.

Bee Ping Teh, Norzahirah Binti Ahmad, Saharuddin Bin Mohamad, Terence Yew Chin Tan, Mohd Ridzuan Bin Mohd Abd Razak, Adlin Binti Afzan, Ami Fazlin Binti Syed Mohamed

Nutrients 2022 Apr 11

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The potential therapeutic effect of Carica papaya leaf juice has attracted wide interest from the public and scientists in relieving dengue related manifestations. Currently, there is a lack of evaluated evidence on its juice form. Therefore, this scoping review aims to critically appraise the available scientific evidence related to the efficacy of C. papaya leaf juice in dengue. A systematic search was performed using predetermined keywords on two electronic databases (PubMed and Google Scholar). Searched results were identified, screened and appraised to establish the association between C. papaya and alleviating dengue associated conditions. A total of 28 articles (ethnobotanical information: three, in vitro studies: three, ex vivo studies: one, in vivo study: 13, clinical studies: 10) were included for descriptive analysis, which covered study characteristics, juice preparation/formulations, study outcomes, and toxicity findings. Other than larvicidal activity, this review also reveals two medicinal potentials of C. papaya leaf juice on dengue infection, namely anti-thrombocytopenic and immunomodulatory effects. C. papaya leaf juice has the potential to be a new drug candidate against dengue disease safely and effectively.

Citation

Bee Ping Teh, Norzahirah Binti Ahmad, Saharuddin Bin Mohamad, Terence Yew Chin Tan, Mohd Ridzuan Bin Mohd Abd Razak, Adlin Binti Afzan, Ami Fazlin Binti Syed Mohamed. Carica papaya Leaf Juice for Dengue: A Scoping Review. Nutrients. 2022 Apr 11;14(8)