Lay A TRAP for myeloid cell response in diabetic kidney disease.

Hiroshi Nishi

Kidney international 2022 May

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The functions of the renin-angiotensin system are crucial in the progression of diabetic kidney disease. ATRAP is a type 1 angiotensin II receptor-associated protein that negatively regulates intracellular angiotensin II signaling. In this issue, Haruhara et al. revealed that ATRAP deficiency of diabetic mice decreases anti-inflammatory macrophage infiltration and exacerbates albuminuria. The adoptive transfer and tubule-specific depletion of ATRAP highlight the crosstalk between glomerular injury and tubulointerstitial angiotensin II signaling and innate immunity. Copyright © 2022 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.