Is type 2 diabetes mellitus another intercellular junction-related disorder?

Carla B Collares-Buzato, Carolina Pf Carvalho

Experimental biology and medicine (Maywood, N.J.) 2022 May

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Type 2 diabetes mellitus (T2D) is nowadays a worldwide epidemic and has become a major challenge for health systems around the world. It is a multifactorial disorder, characterized by a chronic state of hyperglycemia caused by defects in the production as well as in the peripheral action of insulin. This minireview highlights the experimental and clinical evidence that supports the novel idea that intercellular junctions (IJs)-mediated cell-cell contacts play a role in the pathogenesis of T2D. It focuses on IJs repercussion for endocrine pancreas, intestinal barrier, and kidney dysfunctions that contribute to the onset and evolution of this metabolic disorder.

Citation

Carla B Collares-Buzato, Carolina Pf Carvalho. Is type 2 diabetes mellitus another intercellular junction-related disorder? Experimental biology and medicine (Maywood, N.J.). 2022 May;247(9):743-755