Review of air concentrations of pesticides for estimating exposure to vapour in European risk assessments.

In current European non-dietary risk assessment for bystanders and residents, one of the plant protection product exposure pathways to be addressed is vapour inhalation. At present, active ingredients are grouped according to vapour pressure and assigned corresponding values. Risk assessments are driven by only two default air concentration values. Sampling is inconsistent, background data are sparse and many factors having an impact on air concentrations are not considered. Within the changing regulatory landscape over the last 20 years, criteria for volatility grouping and consequently for vapour exposure estimation have been applied heterogeneously. Here we review the background data currently used in the exposure assessment guidance to demonstrate the arbitrary nature of derived air concentration values and their inconsistent application in exposure assessment. In doing so we discuss air concentration from a risk assessment perspective and how active ingredients are grouped according to vapour pressure. We examine the database which at present forms the basis for predicting inhalation exposure to PPPs, particularly the two concentration levels driving risk assessments, and we discuss several other factors having an impact on air concentration. In conclusion, we recommend an urgent revision of the default air concentration values and assumptions applied in assessing vapour exposure. Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Citation

Edgars Felkers, Felix M Kluxen, Sarah Adham, Anne-Kim Vinck, Neil Morgan. Review of air concentrations of pesticides for estimating exposure to vapour in European risk assessments. Regulatory toxicology and pharmacology : RTP. 2022 Jul;132:105172

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PMID: 35469931

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