NiH-catalyzed dearomative hydroalkylation of indoles.

A NiH-catalyzed intermolecular dearomative hydroalkylation of indoles has been developed, which assembles an array of structurally diverse C2-alkylated indolines with moderate to excellent yields. This protocol exhibits good functional group tolerance, allowing for late-stage functionalization of complex drug molecules.

Citation

Kai Liu, Yu-Feng Song, Yang Gao, Jie-Qiong Luo, Yi-Xia Jia. NiH-catalyzed dearomative hydroalkylation of indoles. Chemical communications (Cambridge, England). 2022 May 12;58(39):5893-5896

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PMID: 35474004

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