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A one-pot Curtius rearrangement of dienyl carboxylic acids followed by a 6π-electrocyclization process to form substituted 2-pyridone products has been developed. Dienyl isocyanates generated from aliphatic acids were more reactive than their aromatic counterparts. Additionally, substitution patterns of the carboxylic acids had an impact on the efficiency of the cyclization.


Xiayun Cheng, Alexandria P Taylor, Kaicheng Zhu. Synthesis of Substituted 2-Pyridones via 6π-Electrocyclization of Dienyl Isocyanates. The Journal of organic chemistry. 2022 May 06;87(9):6403-6409

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PMID: 35476425

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