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To investigate factors associated with increased bone mineral density (BMD) of the neck of femur in rheumatoid arthritis or collagen diseases receiving denosumab, focusing on body composition calculated by bioelectrical impedance analysis (n=90, 78 females). We defined Δfemur as BMD (12 months minus baseline), using dual-energy X-ray absorptiometry after denosumab therapy. Factors associated with Δfemur were retrospectively investigated. Low skeletal muscle index (SMI) was observed in 6 males and 32 females. There was a significant difference in phase angle (PhA) of the left leg (LL) between the Δfemur ≥0 (n=70) and Δfemur <0 (n=20) groups (p=0.040) but not in SMI (p=0.310). Multiple regression analysis indicated that PhA of LL was significantly related to Δfemur (p=0.0398). PhA appears to be a clinically significant indicator of improvement of Δfemur in patients receiving denosumab. Copyright © 2022, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.


Mai Nakano, Akimitsu Miyake, Ryuichiro Egashira, Mariko Takeuchi, Misaki Moriguchi, Satoko Tonari, Hitomi Saito, Hiroki Nishikawa, Kiyoshi Matsui, Keisuke Hagihara. Clinical Importance of Body Composition in Improving Bone Mineral Density of Femoral Neck After Denosumab Therapy in Patients With Rheumatoid Arthritis or Collagen Diseases. In vivo (Athens, Greece). 2022 May-Jun;36(3):1468-1476

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PMID: 35478104

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