Zymogen-poor acinic cell carcinoma of the soft palate with high-grade transformation.

T G Kallarakkal, S M Ismail, Y C Goh

The Malaysian journal of pathology 2022 Apr

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Acinic cell carcinoma is an uncommon malignant salivary gland tumour accounting for approximately 6-7% of all salivary gland neoplasms. The key diagnostic feature of acinic cell carcinoma is the presence of acinar cell differentiation characterised by cytoplasmic zymogen secretory granules. This tumour shows a variety of growth patterns, including solid, microcystic, follicular and papillary cystic patterns. Acinic cell carcinoma is typically a cytologically low-grade malignancy. Acinic cell carcinomas with high-grade transformation (HGT) are exceedingly rare and are reported to have a more aggressive clinical course than conventional acinic cell carcinoma. This is a case report of this uncommon entity with high-grade transformation arising on the soft palate in a 64-year-old woman.

Citation

T G Kallarakkal, S M Ismail, Y C Goh. Zymogen-poor acinic cell carcinoma of the soft palate with high-grade transformation. The Malaysian journal of pathology. 2022 Apr;44(1):121-127