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There is a constant need for deuterium-labelled products for multiple applications in life sciences and beyond. Here, a new class of heterogeneous catalysts is reported for practical deuterium incorporation in anilines, phenols, and heterocyclic substrates. The optimal material can be conveniently synthesised and allows for high deuterium incorporation using deuterium oxide as isotope source. This new catalyst has been fully characterised and successfully applied to the labelling of natural products as well as marketed drugs. © 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.

Citation

Florian Bourriquen, Nils Rockstroh, Stephan Bartling, Kathrin Junge, Matthias Beller. Manganese-Catalysed Deuterium Labelling of Anilines and Electron-Rich (Hetero)Arenes. Angewandte Chemie (International ed. in English). 2022 Jul 04;61(27):e202202423

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PMID: 35484978

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