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    Reported herein is an in situ-generated hypervalent iodine-incorporating fluoroarylation of benzylidenecyclopropanes using commercially available HF·Py and aryl iodides as fluorine and aryl sources, respectively. The reaction proceeds via regioselective 1,2-fluoroiodination of a double bond followed by an iodonio-[3,3]-rearrangement of the formed cyclopropyl-I(III) species. The protocol offers facile access to valuable monofluorinated 1,1-bis-benzyl-alkenes with mild reaction conditions and moderate to good yields. The synthetic utility of the products was demonstrated by further transformations. Preliminary mechanistic studies were conducted.


    Long-Ling Huang, Peng-Peng Lin, Yu-Xin Li, Si-Xin Feng, Fang-Hai Tu, Shuang Yang, Gui-Yang Zhao, Zhi-Shu Huang, Honggen Wang, Qingjiang Li. Oxidative Fluoroarylation of Benzylidenecyclopropanes with HF·Py and Aryl Iodides via Iodonio-[3,3]-Rearrangement. Organic letters. 2022 May 13;24(18):3389-3394

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    PMID: 35486481

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