PPAR-δ: A key nuclear receptor in vascular function and remodeling.

Lei Xiao, Nanping Wang

Journal of molecular and cellular cardiology 2022 Aug

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Vascular function is critical for the maintenance of body's homeostasis and is tightly regulated by complex interactions among the vessel wall, hemodynamics, neuro-endocrine factors and metabolic alteration. A variety of cardiovascular risks instigate pro-inflammatory and oxidative responses to impair vascular function, leading to pathological vascular remodeling. Peroxisome proliferator-activated receptor-δ (PPAR-δ) is a ligand-activated nuclear receptor and transcription factor that regulates cell growth and differentiation, metabolism and wound healing. Being expressed in vascular endothelial cells, smooth muscle cells and monocytes, PPAR-δ has pleotropic effects in vascular biology and pathology. In this review, we discussed recent advances regarding the functional roles of PPAR-δ as a critical regulator of vascular homeostasis and as a potential target for the intervention of cardiovascular diseases. Copyright © 2022 Elsevier Ltd. All rights reserved.

Citation

Lei Xiao, Nanping Wang. PPAR-δ: A key nuclear receptor in vascular function and remodeling. Journal of molecular and cellular cardiology. 2022 Aug;169:1-9