Response to Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis".

J Terreros-Roncal, E P Moreno-Jiménez, M Flor-García, C B Rodríguez-Moreno, M F Trinchero, B Márquez-Valadez, F Cafini, A Rábano, M Llorens-Martín

Science (New York, N.Y.) 2022 Apr 15

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Rakic and colleagues challenge the use of extensively validated adult hippocampal neurogenesis (AHN) markers and postulate an alternative interpretation of some of the data included in our study. In Terreros-Roncal et al., reconstruction of the main stages encompassed by human AHN revealed enhanced vulnerability of this phenomenon to neurodegenerative diseases. Here, we clarify points and ambiguities raised by these authors.

Citation

J Terreros-Roncal, E P Moreno-Jiménez, M Flor-García, C B Rodríguez-Moreno, M F Trinchero, B Márquez-Valadez, F Cafini, A Rábano, M Llorens-Martín. Response to Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis". Science (New York, N.Y.). 2022 Apr 15;376(6590):eabn7270